Breakthrough supplement helps slow aging and boost weight loss

Breakthrough supplement helps slow aging and boost weight loss

Science-backed combination supplement, GLYLO, helps slow aging, reduce weight gain, and provides menopause support 

This article was written by Dr. Pankaj Kapahi, Professor at the Buck Institute for Aging Research, California. Dr. Kapahi’s lab has been studying the role of glycation and fasting in aging and menopause for the last 3 decades. His team discovered the breakthrough supplement GLYLO.


 In this article, we will discuss:

1. A sugar addicted society?              

2. Sugar proof your life with GLYLO.

3. How does GLYLO work?

4. How to use GLYLO?

5. The science behind the ingredients of GLYLO.


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1. A sugar-addicted society 

Nearly two-thirds of Americans are overweight and more than 10% are diabetic. We consume more than 50-fold sugar per person compared to our ancestors almost 200 hundred years ago.

Increased consumption of carbohydrates and simple sugars drives the risk of several chronic and age-related diseases including diabetes, cancer, cardiovascular and neurodegenerative diseases. 

To meet this aim, Dr. Pankaj Kapahi, Ph.D., and his scientific research team from the Buck Institute for Research on Aging, California, have identified a unique and for the first time an 'anti-aging weight loss supplement' aka GLYLO

GLYLO safely reduces the sugar craving and sugar induced damage to aid weight loss and slow aging especially post menopause. 

2. Sugar proof your life with GLYLO

The basic principle of this product is to target a biological process called glycation, which happens both in our body and while cooking.

Glycation creates strong bonds between sugar (like glucose and fructose) with protein and fat by producing Accumulated Glycation End-products (AGEs).

This helps to develop the flavor and taste of the food. However, it also leads to various chemical changes within the body, including an increased generation of free radicals, AGEs-dependent increased appetite, inflammation, cellular damage, and damage to blood vessels. 

The preclinical trial scientific data of GLYLO show promising results in mice. The mice display a reduction in body weight and a reduction in appetite.

Furthermore, it improves post-menopausal health by helping maintain muscle and enhance fat burning

The appetite suppressant effect comes from blocking the effects of ghrelin, the hunger hormone in our bodies.

The mice show improved insulin sensitivity and reduced blood glucose.

One of the most striking effects is the ability of GLYLO to extend the lifespan of mice that are already old (almost 60 years of age in human terms).

These benefits are accompanied by an increase in physical activity and muscle mass.

GLYLO has received IND approval from the FDA to be tested in humans and multiple human trials are on the way.

However, all 5 components have been tested individually in multiple human trials and the results of these trials and the benefits of the individual ingredients are summarized here.

Early indications are promising and the team is optimistic about the outcome. 

Dr. Kapahi explains, "Our work has relevance to certain age-related human diseases, including diabetes, Alzheimer's disease, muscle loss, kidney disease, intestinal diseases, and obesity." 

3. How does GLYLO work?


GLYLO targets AGEs by reducing their formation and enhancing their detoxification to provide a better and simpler solution for AGEs-related toxification.

It helps in reducing AGEs, which in turn stimulates healthy aging.

In a recent interview with Longevity Technology, Dr. Kapahi mentioned, "We believe that AGEs contribute to several age-related diseases and diabetic complications.

In a recent podcast, Dr. Kapahi discusses how GLYLO helps in reducing sugar craving, weight management, reducing insulin resistance, and slowing aging. 

He added, "They go up with aging and in patients with Parkinson's, Alzheimer's, cardiovascular disease, diabetic retinopathy, neuropathy, and so on. So that's why we think methylglyoxal is an important target. We developed GLYLO as a product to limit the production of AGEs in vivo, by targeting methylglyoxal."

GLYLO: A blend of 5 ingredients with multiple benefits 



benefits of glylo


4. How to use GLYLO? 

GLYLO can be used both by people with normal weight for its antiaging effects, maintaining muscle mass and improving insulin sensitivity and overweight people for these benefits plus body weight maintenance. 

managing weigh loss and anti aging

Here are 5 key pillars of health including GLYLO that we recommend in our program to help with weight loss and have a more productive life in general. 

These 5 steps may appear to be difficult but your goal should be to make them habits and part of your lifestyle so that it doesn't require will power but becomes a habit like brushing your teeth. 

These 5 pillars are:

  1. Intermittent fasting- this has now been well established in several studies to be a very effective way to not just cut calories but a sustainable way to stay healthy and lose weight. Take a look at this blog for more information. we suggest starting with 12-14 hrs if you are new and going to 16hrs a day 
    Read more10 reasons why fasting could be your elixir of life
  1. Exercise- There is no replacement for this. Our studies show that GLYLO enhances the benefits of exercise. Also, as you get used to this, we recommend fasting cardio which allows helping burn fat further. Fasting cardio is undertaking aerobic exercise when you are fasted, like first thing in the morning, which helps fat burn further.
  1. Healthy diet. A largely plant based diet can add upto 13 years to your life and more than 8.8 years after the age of 60.
    Read more -Check these plant based recipes on our food blog
  1. Health literacy- staying aware of our behaviour and being aware of the science behind staying healthy. We have written some key blogs on relevant topics which are easily accessible. Also, we send a regular newsletter if you sign up on our website.
    Read more - Science blog

  1. Taking GLYLO- 2 pills in the morning. GLYLO seems to also enhance the effects of exercise so if you can keep up the exercise it may help more. If you are a coffee drinker then having it in the morning with an early morning workout routine with GLYLO may be a good idea. 

For weight loss, we recommend 3 pills/ day with ample water. Staying hydrated is also key to burning fat. 

Dr. Kapahi concludes, “ I have been using GLYLO for the last 2 years and derived several benefits including more stamina, lowering blood sugar, and reduced sugar cravings. Our vision is to help individuals derive the benefits of fasting and calorie restriction to enhance healthspan by utilizing micronutrients and easy-to-incorporate lifestyle changes.” 

GLYLO is the brainchild of this far-sighted science-backed goal to enhance the adherence to a healthy lifestyle.

The individual components act synergistically by engaging multiple targets that promote health. These include:

  • reducing carbohydrate intake, 
  • promoting fat burning, 
  • enhancing NAD+, 
  • enhancing glutathione
  • lowering advanced glycation end products (AGEs), 
  • reducing senescence, 
  • and promoting cellular repair pathways. 

The product is designed to help achieve your fasting goals and lower calorie intake.

5. The science behind the ingredients in GLYLO

Alpha Lipoic acid (ALA)

ALA — produced both in plants and animals — are naturally synthesized in mitochondria and function as cofactors (its presence is necessary for the activity of an enzyme) of certain enzymes aiding in cellular energy production. 

Our body typically produces ALA to help the enzymes carry out their assigned functions properly. Although present in a meager amount, ALA could be found in various leafy vegetables (e.g., spinach, broccoli, brussels sprout); potatoes; tomatoes; peas; beats; carrots, etc.

Health benefits of ALA

Because of its role in antioxidant defenses, ALA is linked to numerous anti-aging benefits, including better nerve function, reducing blood sugar levels, anti-inflammatory responses, and decelerating skin aging. 

ALA's added benefits span from serving in glucose metabolism antioxidant defenses to anti-inflammatory responses — several more are listed in the table below.


Description and references

Oxidative stress

Scavenges reactive oxygen species, regenerate endogenous antioxidants — vitamin C, glutathione. 


Stimulates telomerase,
Reduces skin aging


Lowers blood sugar,
reduces diabetic neuropathy,
helps in diabetic retinopathy


ALA as a supplement for weight loss (meta-analyses: 1, 2, 3)  


Inhibits HIV replication, various immunomodulatory effects

Cardiovascular disease 

lowers blood pressure in rats,
better vascular function and decreases atherosclerotic plaque,
increases the synthesis of Nitric oxide


Improves spatial memory, learning capacity, and/or motor function in animal modelsslows cognitive decline,
defends neurons from β-amyloid peptide and peroxide-mediated cytotoxicity


Aging goes hand in hand with the accumulation of damaged proteins and reactive metabolites. AGEs are one among the many toxic products generated by the glycation of macromolecules. Treatment with ALA inhibits AGEs generation supporting the anti-glycation role of ALA


Nicotinamide (NAM), an active form of vitamin B3, is the dietary source of nicotinamide adenine dinucleotide (NAD+). This is commonly used for medication specifically to treat pellagra caused by niacin deficiency. In addition, this has a beneficiary effect on various memory and aging-related diseases treatments.

The lower level of NAD+ directly drives aging and other age-related diseases. Dietary NAM supplements can increase NAD+ levels within a very short period, with low side effects. 

Health benefits of NAM

NAM is essential for NAD+ biosynthesis and intracellular ATP generation, increasing cellular reactive oxygen species (ROS) production and NAD+ level. The role and advantages of NAM are tabulated below: 


Description and references

Oxidative stress

protects against DNA damage and oxidative stress


NAD+ biosynthesis, ATP generation, ROS generation, the aging process in the skeletal muscle. 


improves glucose metabolism in the liver,
insulin secretion,
metabolic control,
maintains mitochondrial integrity,


regulates energy and alters adipose phenotype,
increases SIRT1 activity in liver

Inflammatory reactions

Increases pancreatic β-cell viability and function reduces pro-inflammatory cytokines, reduces the generation of superoxide, limits the pro-inflammatory tissue environments, nitric oxide-mediated inflammation


High NAD+ protects from cancer development 


Increases neurotransmitters, betters cognitive functions, prevents dementia and neurodegenerative disease


Thiamine or Vitamin B1

Thiamine or vitamin B1 is an essential vitamin that helps produce energy from food through glucose metabolism. Diet is the only source of thiamine for us as our body cannot synthesize this vitamin. Regulation of this vitamin level through dietary supplements is a standard treatment for several diseases. 

Health benefits of Thiamine

Thiamine can prevent various neurodegenerative diseases and promote healthy aging if consumed as dietary supplement. Important roles of thiamine are listed below: 


Description and references

Oxidative stress

limits oxidative stress


Prevents generation of AGEs


Decreases blood glucose,
rescues red-cell thiamine levels,
reduces vascular damage,
decreases the expression of fatty acid synthase,
prevents hyperglycemia-mediated cell proliferation,
reduces diabetic nephropathy

Blood pressure

Reduces vascular complications,
controls blood pressure,


increases the antioxidant capacity of plasma in dialysis patients


Prevents fatty liver development, decreases hepatic fat content, increases hepatic glycogen content, and reduces gene expression related to hepatic steatosis

Cell damage

Inhibits lipid peroxidation


Prevents myocardial ischemia


Improves glucose metabolism,
reduces amyloid plaques and phosphorylation tau, and protects against Alzheimer’s disease.


Pyridoxine or Vitamin B6

Pyridoxine, a form of vitamin B6, is a water-soluble vitamin, present in various foods like meat, nuts, whole grains, and fruits. It is essential for the metabolism of carbohydrates, amino acids, lipids, DNA, and neurotransmitters within the body. It plays a vital role in red blood cell production to prevent anemia.

Health benefits of vitamin B6

Vitamin B6 is significant for treating chronic diseases, including diabetes, cancer, autism, neurodegenerative disorders, etc. Some of the health benefits of vitamin B6 are listed below: 


Description and references

Oxidative stress

Reduces oxidative stress and inflammatory response


Counteracts the formation of ROS and glycation products (AGEs) 


Protects against diabetic retinopathy,
ameliorates lipid peroxidation and insulin resistance


Inhibits the progression of renal disease and reduces hyperlipidemia


Reduces elevated blood levels of homocysteine and lowers the risk of age-related macular degeneration (AMD)


Prevents aortic stiffening and improves arterial function


Decreases high homocysteine blood levels that may increase the risk of Alzheimer’s



Piperine is the chief bio-active element of pepper, which presents pungency and its bitter taste. This naturally obtainable alkaloid possesses abundant health effects and beneficial therapeutic properties. Piperine is widely used as part of traditional medicines in several countries, and it could increase the bioavailability of several drugs.


Description and references


Help in treating viral infections


A potent drug against obesity-related diseases,
reduces body weight and improves insulin and leptin sensitivity in rats

Oxidative stress

Piperine in combination with curcumin found to reduce oxidative stress caused by D-galactose,
which is deleterious for brain function and can lead to cerebellar atrophy during aging

Brain and memory

Reduces endoplasmic reticulum stress in the spinocerebellar ataxia model and plays a protective role against neuropathology,
improves memory


Reduces joint swelling and inflammationsuppresses inflammation in the airways caused by asthma and seasonal allergies

Blood sugar

Helps improve blood sugar metabolism


The synergy between these 5 ingredients makes GLYLO special and an effective formula to slow down the overall process of aging and complement weight loss. 


Would you like to experience the benefits of GLYLO and join the over 10,000 GLYLO users? Go, and grab this opportunity; GLYLO is now available on Amazon